Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies.

ABSTRACT: Communication between the brain and peripheral mediators of systemic inflammation is implicated in numerous psychological, behavioral, and physiological processes. Functional neuroimaging studies have identified brain regions that associate with peripheral inflammation in humans, yet there are open questions about the consistency, specificity, and network characteristics of these findings. The present systematic review provides a meta-analysis to address these questions. Multilevel kernel density analysis of 24 studies (37 statistical maps; 264 coordinates; 457 participants) revealed consistent effects in the amygdala, hippocampus, hypothalamus, striatum, insula, midbrain, and brainstem, as well as prefrontal and temporal cortices. Effects in some regions were specific to particular study

SUBMITTER: Kraynak TE 

PROVIDER: S-EPMC6363360 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature