A Genome-Wide Association Study for Susceptibility to Visual Experience-Induced Myopia.

ABSTRACT:

Purpose

The rapid rise in prevalence over recent decades and high heritability of myopia suggest a role for gene-environment (G × E) interactions in myopia susceptibility. Few such G × E interactions have been discovered to date. We aimed to test the hypothesis that genetic analysis of susceptibility to visual experience-induced myopia in an animal model would identify novel G × E interaction loci.

Methods

Chicks aged 7 days (n = 987) were monocularly deprived of form vision for 4 days. A genome-wide association study (GWAS) was carried out in the 20% of chicks most susceptible and least susceptible to form deprivation (n = 380). There were 304,963 genetic markers tested for association with the degree of induced axial elongation in treated versus control eyes (A-scan ultras

SUBMITTER: Huang Y 

PROVIDER: S-EPMC6363377 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature