Ontology highlight
ABSTRACT:
SUBMITTER: Byrum AK
PROVIDER: S-EPMC6363440 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
The Journal of cell biology 20190102 2
53BP1 is a chromatin-associated protein that regulates the DNA damage response. In this study, we identify the TPX2/Aurora A heterodimer, nominally considered a mitotic kinase complex, as a novel binding partner of 53BP1. We find that TPX2/Aurora A plays a previously unrecognized role in DNA damage repair and replication fork stability by counteracting 53BP1 function. Loss of TPX2 or Aurora A compromises DNA end resection, BRCA1 and Rad51 recruitment, and homologous recombination. Furthermore, l ...[more]