Ontology highlight
ABSTRACT:
SUBMITTER: Niu F
PROVIDER: S-EPMC6363463 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
The Journal of cell biology 20190109 2
Cocaine is known to facilitate the transmigration of inflammatory leukocytes into the brain, an important mechanism underlying neuroinflammation. Pericytes are well-recognized as important constituents of the blood-brain barrier (BBB), playing a key role in maintaining barrier integrity. In the present study, we demonstrate for the first time that exposure of human brain vascular pericytes to cocaine results in enhanced secretion of CXCL10, leading, in turn, to increased monocyte transmigration ...[more]