The blood transcriptional signature for active and latent tuberculosis.

ABSTRACT:

Background

Although the incidence of tuberculosis (TB) has dropped substantially, it still is a serious threat to human health. And in recent years, the emergence of resistant bacilli and inadequate disease control and prevention has led to a significant rise in the global TB epidemic. It is known that the cause of TB is Mycobacterium tuberculosis infection. But it is not clear why some infected patients are active while others are latent.

Methods

We analyzed the blood gene expression profiles of 69 latent TB patients and 54 active pulmonary TB patients from GEO (Transcript Expression Omnibus) database.

Results

By applying minimal redundancy maximal relevance and incremental feature selection, we identified 24 signature genes which can predict the TB activation

SUBMITTER: Deng M 

PROVIDER: S-EPMC6363485 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature