Controlled-releasing hydrogen sulfide donor based on dual-modal iron oxide nanoparticles protects myocardial tissue from ischemia-reperfusion injury.

ABSTRACT:

Background

Hydrogen sulfide (H₂S) has shown promising therapeutic benefits in reversing a variety of pathophysiological processes in cardiovascular system, including myocardial ischemia-reperfusion (IR) injury. However, the achievement of controlled and sustained release of H₂S has been a technical bottleneck that limits the clinical application of the gas molecule.

Methods

The current study describes the development of mesoporous iron oxide nanoparticles (MIONs) which were loaded with diallyl trisulfide (DATS), a H₂S donor compound, and calibrated by stimulated Raman scattering/transient absorption.

Results

The synthesized MIONs were characterized with excellent mesoporosity and a narrow size distribution, which enabled them to slow d

SUBMITTER: Wang W 

PROVIDER: S-EPMC6363493 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature