Diet, Gut Microbiota, and Obesity: Links with Host Genetics and Epigenetics and Potential Applications.

ABSTRACT: Diverse evidence suggests that the gut microbiota is involved in the development of obesity and associated comorbidities. It has been reported that the composition of the gut microbiota differs in obese and lean subjects, suggesting that microbiota dysbiosis can contribute to changes in body weight. However, the mechanisms by which the gut microbiota participates in energy homeostasis are unclear. Gut microbiota can be modulated positively or negatively by different lifestyle and dietary factors. Interestingly, complex interactions between genetic background, gut microbiota, and diet have also been reported concerning the risk of developing obesity and metabolic syndrome features. Moreover, microbial metabolites can induce epigenetic modifications (i.e., changes in DNA methylation and micr

SUBMITTER: Cuevas-Sierra A 

PROVIDER: S-EPMC6363528 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature