A Comprehensive Analysis of Population Differences in LRRK2 Variant Distribution in Parkinson's Disease.

ABSTRACT: Background: LRRK2 variants have been demonstrated to have distinct distributions in different populations. However, researchers have thus far chosen to focus on relatively few variants, such as R1628P, G2019S, and G2385R. We therefore investigated the relationship between common LRRK2 variants and PD risk in various populations. Methods: Using a set of strict inclusion criteria, six databases were searched, resulting in the selection of 94 articles covering 49,299 cases and 47,319 controls for final pooled analysis and frequency analysis. Subgroup analysis were done for Africans, European/West Asians, Hispanics, East Asians, and mixed populations. Statistical analysis was carried out using the Mantel-Haenszel approach to determine the relationship between common

SUBMITTER: Shu L 

PROVIDER: S-EPMC6363667 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature