Defining Key Genes Regulating Morphogenesis of Apocrine Sweat Gland in Sheepskin.

ABSTRACT: The apocrine sweat gland is a unique skin appendage in humans compared to mouse and chicken models. The absence of apocrine sweat glands in chicken and murine skin largely restrains further understanding of the complexity of human skin biology and skin diseases, like hircismus. Sheep may serve as an additional system for skin appendage investigation owing to the distributions and histological similarities between the apocrine sweat glands of sheep trunk skin and human armpit skin. To understand the molecular mechanisms underlying morphogenesis of apocrine sweat glands in sheepskin, transcriptome analyses were conducted to reveal 1631 differentially expressed genes that were mainly enriched in three functional groups (cellular component, molecular function and biological process), particula

SUBMITTER: Li S 

PROVIDER: S-EPMC6363705 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature