Inferring pathogen-host interactions between Leptospira interrogans and Homo sapiens using network theory.

ABSTRACT: Leptospirosis is the most emerging zoonotic disease of epidemic potential caused by pathogenic species of Leptospira. The bacterium invades the host system and causes the disease by interacting with the host proteins. Analyzing these pathogen-host protein interactions (PHPIs) may provide deeper insight into the disease pathogenesis. For this analysis, inter-species as well as intra-species protein interactions networks of Leptospira interrogans and human were constructed and investigated. The topological analyses of these networks showed lesser connectivity in inter-species network than intra-species, indicating the perturbed nature of the inter-species network. Hence, it can be one of the reasons behind the disease development. A total of 35 out of 586 PHPIs were identified as key interac

SUBMITTER: Kumar S 

PROVIDER: S-EPMC6363727 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature