Accuracy of a Novel Histoplasmosis Enzyme Immunoassay to Evaluate Suspicious Lung Nodules.

ABSTRACT:

Background

Granulomas caused by infectious lung diseases present as indeterminate pulmonary nodules (IPNs) on radiography. Newly available serum enzyme immunoassay (EIA) for histoplasmosis has not been studied for the evaluation of IPNs. We investigated serum biomarkers of histoplasmosis antibodies as an indication of benign disease in IPNs from a highly endemic region.

Methods

A total of 152 serum samples from patients presenting with pulmonary nodules ≤30 mm in maximum diameter were analyzed for histoplasmosis antibodies by immunodiffusion and EIA IgG and IgM tests. Serology and FDG-PET/CT scan diagnostic test characteristics were estimated and compared.

Results

Cancer prevalence was 55% (n = 83). Thirty-nine (26%) individuals were positive for IgG histoplasm

SUBMITTER: Deppen SA 

PROVIDER: S-EPMC6363824 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature