Children with Neutrophil-Predominant Severe Asthma Have Proinflammatory Neutrophils With Enhanced Survival and Impaired Clearance.

ABSTRACT:

Background

Airway neutrophils are abundant in some children with severe asthma, but their functions are poorly understood.

Objective

To characterize that the inflammatory airway environment of children with neutrophil-predominant severe asthma promotes neutrophil survival and disrupts neutrophil-associated innate immune defenses.

Methods

Sixty-seven children with severe asthma refractory to high-dose inhaled corticosteroid treatment undergoing bronchoscopy with bronchoalveolar lavage (BAL) for clinical indications were stratified into neutrophil "high" versus "low" groups on the basis of BAL differential counts. Neutrophil activation markers, functional assays, and phenotyping studies were performed, as well as airway macrophage functional assays. Results were compare

SUBMITTER: Grunwell JR 

PROVIDER: S-EPMC6363859 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature