Longitudinal association between inflammatory markers and specific symptoms of depression in a prospective birth cohort.

ABSTRACT:

Background

Low-grade inflammation is associated with depression, but studies of specific symptoms are relatively scarce. Association between inflammatory markers and specific symptoms may provide insights into potential mechanism of inflammation-related depression. Using longitudinal data, we have tested whether childhood serum interleukin 6 (IL-6) and C-reactive protein (CRP) levels are associated with specific depressive symptoms in early adulthood.

Methods

In the ALSPAC birth cohort, serum IL-6 and CRP levels were assessed at age 9 years and 19 depressive symptoms were assessed at age 18 years. We used modified Poisson generalised linear regression with robust error variance to estimate the risk ratio (RR) and 95% confidence interval (95% CI) for each depressive symptom.

SUBMITTER: Chu AL 

PROVIDER: S-EPMC6363967 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature