Club Cell Secretory Protein Deficiency Leads to Altered Lung Function.

ABSTRACT:

Rationale

CC16 (club cell secretory protein-16), a member of the secretoglobin family, is one of the most abundant proteins in normal airway secretions and has been described as a serum biomarker for obstructive lung diseases.

Objectives

To determine whether low CC16 is a marker for airway pathology or is implicated in the pathophysiology of progressive airway damage in these conditions.

Methods

Using human data from the birth cohort of the Tucson Children's Respiratory Study, we examined the relation of circulating CC16 levels with pulmonary function and responses to bronchial methacholine challenge from childhood up to age 32 years. In wild-type and CC16^-/- mice, we set out to comprehensively examine pulmonary physiology, inflammation, and remodeling in t

SUBMITTER: Zhai J 

PROVIDER: S-EPMC6363971 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature