Association between RAGE variants and the susceptibility to atherosclerotic lesions in Chinese Han population.

ABSTRACT: Receptor for advanced glycation end products (RAGE) is a major proinflammatory receptor and its role in atherosclerosis has only been emphasized recently. Increasing evidence has demonstrated an association between RAGE and the susceptibility to atherosclerosis development. Therefore, the role of RAGE in atherogenesis and the possible impact of genetic variations in RAGE on the atherosclerotic process in subjects with coronary artery disease (CAD) was investigated in the present study. The RAGE expression in carotid specimens was analyzed by immunohistochemistry and sequence variations of the RAGE gene selected from the Hapmap database were also screened. The plasma levels of S100 calcium binding protein B (S100B) were determined by ELISA. Immunohistochemical staining of tissue samples dem

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6364181 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature