Focal adhesion kinase (FAK) activation by estrogens involves GPER in triple-negative breast cancer cells.

ABSTRACT:

Background

Focal adhesion kinase (FAK) is a cytoplasmatic protein tyrosine kinase that associates with both integrins and growth factor receptors toward the adhesion, migration and invasion of cancer cells. The G-protein coupled estrogen receptor (GPER) has been involved in the stimulatory action of estrogens in breast tumor. In this study, we have investigated the engagement of FAK by GPER signaling in triple negative breast cancer (TNBC) cells.

Methods

Publicly available large-scale database and patient data sets derived from "The Cancer Genome Atlas" (TCGA; www.cbioportal.org ) were used to assess FAK expression in TNBC, non-TNBC tumors and normal breast tissues. MDA-MB 231 and SUM159 TNBC cells were used as model system. The levels of phosphorylated FAK, other transducti

SUBMITTER: Rigiracciolo DC 

PROVIDER: S-EPMC6364402 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature