Impact of thyroid function on cystatin C in detecting acute kidney injury: a prospective, observational study.

ABSTRACT:

Background

Cystatin C (Cys C) used clinically for detecting early acute kidney injury (AKI) was reported to be associated with thyroid function. Therefore, whether the performance of Cys C is affected by thyroid hormones has raised concern in critically ill patients. This study aimed to investigate the impact of thyroid hormones on the diagnostic and predictive accuracy of Cys C for AKI, and hence optimize the clinical application of Cys C.

Methods

A prospective observational study was conducted in the general intensive care units (ICUs). Serum creatinine (SCr), Cys C, and thyroid function were documented for all patients at ICU admission. Patients were separated into five quintiles based on free triiodothyronine (FT3) and total triiodothyronine (TT3), and two categories acc

SUBMITTER: Zhang D 

PROVIDER: S-EPMC6364411 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature