Estimation of duplication history under a stochastic model for tandem repeats.

ABSTRACT:

Background

Tandem repeat sequences are common in the genomes of many organisms and are known to cause important phenomena such as gene silencing and rapid morphological changes. Due to the presence of multiple copies of the same pattern in tandem repeats and their high variability, they contain a wealth of information about the mutations that have led to their formation. The ability to extract this information can enhance our understanding of evolutionary mechanisms.

Results

We present a stochastic model for the formation of tandem repeats via tandem duplication and substitution mutations. Based on the analysis of this model, we develop a method for estimating the relative mutation rates of duplications and substitutions, as well as the total number of mutations, in the hist

SUBMITTER: Farnoud F 

PROVIDER: S-EPMC6364452 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature