Harnessing Motile Amoeboid Cells as Trucks for Microtransport and -Assembly.

ABSTRACT: Cell-driven microtransport is one of the most prominent applications in the emerging field of biohybrid systems. While bacterial cells have been successfully employed to drive the swimming motion of micrometer-sized cargo particles, the transport capacities of motile adherent cells remain largely unexplored. Here, it is demonstrated that motile amoeboid cells can act as efficient and versatile trucks to transport microcargo. When incubated together with microparticles, cells of the social amoeba Dictyostelium discoideum readily pick up and move the cargo particles. Relying on the unspecific adhesive properties of the amoeba, a wide range of different cargo materials can be used. The cell-driven transport can be directionally guided based on the chemotactic responses of amoeba to che

SUBMITTER: Nagel O 

PROVIDER: S-EPMC6364505 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature