Cytokine, Chemokine, and Cytokine Receptor Changes Are Associated With Metabolic Improvements After Bariatric Surgery.

ABSTRACT:

Context

Altered cytokine levels and chronic low-grade inflammation contribute to metabolic dysfunction in obesity. The extent of cytokine changes and their impact on metabolic improvements after bariatric surgery have not been fully explored.

Objective

To compare 76 circulating cytokines, chemokines, and secreted cytokine receptors in subjects with obesity and lean subjects and determine how these cytokines are altered by bariatric surgery.

Design, setting, and participants

A total of 37 patients with obesity and 37 lean patients in a cross-sectional study at an academic medical center. We also investigated cytokine changes in 25 patients with obesity after bariatric surgery.

Intervention

Bariatric surgery (Roux-en-Y gastric bypass and vertical sleeve gastrecto

SUBMITTER: Wolf RM 

PROVIDER: S-EPMC6364507 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature