Saturated Fat Ingestion Promotes Lipopolysaccharide-Mediated Inflammation and Insulin Resistance in Polycystic Ovary Syndrome.

ABSTRACT:

Context

Inflammation and insulin resistance (IR) are often present in polycystic ovary syndrome (PCOS).

Objective

We determined the effect of saturated fat ingestion on circulating lipopolysaccharide (LPS) and mononuclear cell (MNC) toll-like receptor-4 (TLR-4) and suppressor of cytokine signaling-3 (SOCS-3) in women with PCOS.

Design

Cross-sectional study.

Setting

Academic medical center.

Patients

Nineteen reproductive-age women with PCOS (10 lean, 9 obese) and 19 ovulatory control subjects (10 lean, 9 obese).

Main outcome measures

LPS and TNFα levels were measured in plasma. TLR-4 and SOCS-3 mRNA and protein content were quantified in MNC from blood collected after fasting and 2, 3, and 5 hours after saturated fat ingestion. Insulin sensitivity

SUBMITTER: Gonzalez F 

PROVIDER: S-EPMC6364509 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature