Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions.

ABSTRACT: Linear furocoumarins, also known as psoralens, are clinically useful photo-activated pharmaceuticals employed to address hyperproliferative skin diseases. Seven diverse cytotoxic pharmacophores have been synthetically attached to 8-methoxypsoralen via a 5-amino functionality. The resulting unique set of compounds was evaluated for dark and light toxicity against PAM212 keratinocytes in culture.

SUBMITTER: Guillon CD 

PROVIDER: S-EPMC6364570 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature