Sex-dependent differences in central artery haemodynamics in normal and fibulin-5 deficient mice: implications for ageing.

ABSTRACT: Mouse models provide unique opportunities to study vascular disease, but they demand increased experimental and computational resolution. We describe a workflow for combining in vivo and in vitro biomechanical data to build mouse-specific computational models of the central vasculature including regional variations in biaxial wall stiffness, thickness and perivascular support. These fluid-solid interaction models are informed by micro-computed tomography imaging and in vivo ultrasound and pressure measurements, and include mouse-specific inflow and outflow boundary conditions. Hence, the model can capture three-dimensional unsteady flows and pulse wave characteristics. The utility of this experimental-computational approach is illustrated by comparing central artery bi

SUBMITTER: Cuomo F 

PROVIDER: S-EPMC6364598 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature