Role of genetic heart disease in sentinel sudden cardiac arrest survivors across the age spectrum.

ABSTRACT:

Background

Sudden cardiac arrest (SCA) may be the sentinel expression of a sudden cardiac death-predisposing genetic heart disease (GHD). Although shown to underlie many unexplained SCAs in the young, the contribution of GHDs to sentinel SCA has never been quantified across the age spectrum. Thus, we sought to determine the contribution of GHDs in single-center referral cohort of non-ischemic SCA survivors.

Methods and results

Retrospective analysis of 3037 patients was used to identify all individuals who experienced a sentinel event of SCA. Following exclusion of patients with ischemic or complex congenital heart disease, cases were classified by clinical diagnoses. Overall, 180 (5.9%) referral patients experienced a sentinel SCA (average age at SCA 28 ± 15 years, 99 femal

SUBMITTER: Giudicessi JR 

PROVIDER: S-EPMC6364980 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature