Lack of Ikaros Deregulates Inflammatory Gene Programs in T Cells.

ABSTRACT: CD4 Th cells are organizers of the immune response, directing other immune cells to initiate and maintain effective humoral and cellular immunity. CD4 T cells differentiate into distinct Th effector or regulatory subsets in response to signals delivered to them during the course of infection. Ikaros is a transcription factor that is expressed in blood cells from the level of the hematopoietic stem cell. It is required for normal thymic T cell development and serves as a tumor suppressor, as lack of Ikaros in developing lymphoid cells results in leukemia. To study the role of Ikaros in CD4 T cell differentiation and function, an Ikaros conditional knockout mouse was developed such that Ikaros expression was deleted specifically in mature T cells, thus avoiding defects observed in germline I

SUBMITTER: Lyon de Ana C 

PROVIDER: S-EPMC6365004 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature