New Developments in the Molecular Mechanisms of Pancreatic Tumorigenesis.

ABSTRACT: Pancreatic cancer is an aggressive disease with a dismal prognosis in dire need of novel diagnostic and therapeutic approaches. The past decade has witnessed an explosion of data on the genetic alterations that occur in pancreatic cancer, as comprehensive next-generation sequencing analyses have been performed on samples from large cohorts of patients. These studies have defined the genomic landscape of this disease and identified novel candidates whose mutations contribute to pancreatic tumorigenesis. They have also clarified the genetic alterations that underlie multistep tumorigenesis in precursor lesions and provided insights into clonal evolution in pancreatic neoplasia. In addition to these important insights into pancreatic cancer biology, these large scale genomic studies have also

SUBMITTER: Felsenstein M 

PROVIDER: S-EPMC6365013 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature