Identification of the key genes and long non‑coding RNAs in ankylosing spondylitis using RNA sequencing.

ABSTRACT: Ankylosing spondylitis (AS) is an insidious and debilitating form of arthritis that involves the axial skeleton, and its etiology and pathogenesis remain unclear. In the present study, three patients with AS and three normal controls from our hospital were enrolled. RNA sequencing and bioinformatics analysis were performed in order to identify the differentially expressed (DE) mRNAs (DEmRNAs) and DE long non‑coding RNAs (DElncRNAs) between the patients with AS and normal controls. Construction of an AS‑specific protein‑protein interaction network, a weighted DElncRNA‑DEmRNA co‑expression network and functional annotation of the DEmRNAs co‑expressed with DElncRNAs was performed. Nearby cis‑targeted DEmRNAs or DElncRNAs were identified by searching for DEmRNAs that were transcribed within 10

SUBMITTER: Xu Z 

PROVIDER: S-EPMC6365023 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature