Human consciousness is supported by dynamic complex patterns of brain signal coordination.

ABSTRACT: Adopting the framework of brain dynamics as a cornerstone of human consciousness, we determined whether dynamic signal coordination provides specific and generalizable patterns pertaining to conscious and unconscious states after brain damage. A dynamic pattern of coordinated and anticoordinated functional magnetic resonance imaging signals characterized healthy individuals and minimally conscious patients. The brains of unresponsive patients showed primarily a pattern of low interareal phase coherence mainly mediated by structural connectivity, and had smaller chances to transition between patterns. The complex pattern was further corroborated in patients with covert cognition, who could perform neuroimaging mental imagery tasks, validating this pattern's implication in consciousness. Ane

SUBMITTER: Demertzi A 

PROVIDER: S-EPMC6365115 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature