Iron oxide-carbon core-shell nanoparticles for dual-modal imaging-guided photothermal therapy.

ABSTRACT: Nanostructured materials that have low tissue toxicity, multi-modal imaging capability and high photothermal conversion efficiency have great potential to enable image-guided near infrared (NIR) photothermal therapy (PTT). Here, we report a bifunctional nanoparticle (BFNP, ∼16 nm) comprised of a magnetic Fe₃O₄ core (∼9.1 nm) covered by a fluorescent carbon shell (∼3.4 nm) and prepared via a one-pot solvothermal synthesis method using ferrocene as the sole source. The BFNP exhibits excitation wavelength-tunable, upconverted and near-infrared (NIR) fluorescence property due to the presence of the carbon shell, and superparamagnetic behavior resulted from the Fe₃O₄ core. BFNPs demonstrate dual-modal imaging capacity both in vitro and in vivo with fl

SUBMITTER: Wang H 

PROVIDER: S-EPMC6365181 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature