Single-nucleotide polymorphisms in a cohort of significantly obese women without cardiometabolic diseases.

ABSTRACT:

Background/objectives

Obesity is an important risk factor for the development of diseases such as diabetes mellitus, hypertension, and dyslipidemia; however, a small number of individuals with long-standing obesity do not present with these cardiometabolic diseases. Such individuals are referred to as metabolically healthy obese (MHO) and potentially represent a subgroup of the general population with a protective genetic predisposition to obesity-related diseases. We hypothesized that individuals who were metabolically healthy, but significantly obese (BMI ≥ 35 kg/m²) would represent a highly homogenous subgroup, with which to investigate potential genetic associations to obesity. We further hypothesized that such a cohort may lend itself well to investigate potential g

SUBMITTER: Schlauch KA 

PROVIDER: S-EPMC6365206 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature