Stiffening and ventricular-arterial interaction in the ascending aorta using MRI: ageing effects in healthy humans.

ABSTRACT:

Objectives

The aim of this study was to investigate the effect of age and sex on nPWV and ndI in the ascending aorta of healthy humans.

Background

Local pulse wave velocity (nPWV) and wave intensity (ndI) in the human ascending aorta have not been studied adequately, because of the need for invasive pressure measurements. However, a recently developed technique made the noninvasive determination of nPWV and ndI possible using measurements of flow velocity and arterial diameter.

Methods

Diameter and flow velocity were measured at the level of the ascending aorta in 144 healthy participants (aged 20-77 years, 66 men), using MRI. nPWV, ndI parameters; forward (FCW); backward (BCW) compression waves, forward decompression wave (FDW), local aortic distensibility (nDs) and

SUBMITTER: Li Y 

PROVIDER: S-EPMC6365245 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature