Baicalin induces apoptosis in SW480 cells through downregulation of the SP1 transcription factor.

ABSTRACT: Colorectal cancer occurs throughout the world but is most common in developed countries. Cancer progression is believed to be driven by genetic mutations in this complex condition. Risk factors for developing colorectal cancer include a genetic family history, long-term ulcerative colitis, and colonic polyps. The use of baicalin has been reported to be clinically efficacious against colon tumors in Asian countries despite an unclear mechanism of action. Several cancers have been found to be biologically dependent on the specificity protein 1 (sp1) transcription factor family. We hypothesized that baicalin may exert its chemotherapeutic effects by sp1 downregulation. Using the SW480 human colorectal cancer cell line, we investigated the physiological properties of baicalin. Our experiments

SUBMITTER: Ma W 

PROVIDER: S-EPMC6365257 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature