Subclonal evolution in disease progression from MGUS/SMM to multiple myeloma is characterised by clonal stability.

ABSTRACT: Multiple myeloma (MM) is a largely incurable haematological malignancy defined by the clonal proliferation of malignant plasma cells (PCs) within the bone marrow. Clonal heterogeneity has recently been established as a feature in MM, however, the subclonal evolution associated with disease progression has not been described. Here, we performed whole-exome sequencing of serial samples from 10 patients, providing new insights into the progression from monoclonal gammopathy of undetermined significance (MGUS) and smouldering MM (SMM), to symptomatic MM. We confirm that intraclonal genetic heterogeneity is a common feature at diagnosis and that the driving events involved in disease progression are more subtle than previously reported. We reveal that MM evolution is mainly characterised by the

SUBMITTER: Dutta AK 

PROVIDER: S-EPMC6365384 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature