C-X (X = N, O) Cross-Coupling Reactions Catalyzed by Copper-Pincer Bis(N-Heterocyclic Carbene) Complexes.

ABSTRACT: Over the last two decades, N-heterocyclic carbene (NHC)-copper catalysts have received considerable attention in organic synthesis. Despite the popularity of copper complexes containing monodentate NHC ligands and recent development of poly(NHC) platforms, their application in C-C and C-heteroatom cross-coupling reactions has been limited. Recently, we reported an air-assisted Sonogashira-type cross-coupling catalyzed by well-defined cationic copper-pincer bis(NHC) complexes. Herein, we report the application of these complexes in Ullmann-type C-X (X = N, O) coupling of azoles and phenols with aryl halides in a relatively short reaction time. In contrast to other well-defined copper(I) catalysts that require an inert atmosphere for an efficient C-X coupling, the employed Cu(I)-pincer bis(N

SUBMITTER: Minnick JL 

PROVIDER: S-EPMC6365418 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature