PTX3 Polymorphisms Influence Cytomegalovirus Reactivation After Stem-Cell Transplantation.

ABSTRACT: Background: Reactivation of latent human cytomegalovirus (CMV) in patients undergoing allogeneic stem-cell transplantation (HSCT) predisposes to several clinical complications and is therefore a major cause of morbidity and mortality. Although pentraxin-3 (PTX3) has been previously described to bind both human and murine CMV and mediate several host antiviral mechanisms, whether genetic variation in the PTX3 locus influences the risk of CMV infection is currently unknown. Methods: To dissect the contribution of genetic variation within PTX3 to the development of CMV infection, we analyzed described loss-of-function variants at the PTX3 locus in 394 recipients of HSCT and their corresponding donors and assessed the associated risk of CMV reactivation. R

SUBMITTER: Campos CF 

PROVIDER: S-EPMC6365436 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature