Plasmodium falciparum specific helicase 2 is a dual, bipolar helicase and is crucial for parasite growth.

ABSTRACT: Human malaria infection is a major challenge across the globe and is responsible for millions of deaths annually. Rapidly emerging drug resistant strains against the new class of anti-malarial drugs are major threat to control the disease burden worldwide. Helicases are present in every organism and have important role in various nucleic acid metabolic processes. Previously we have reported the presence of three parasite specific helicases (PSH) in Plasmodium falciparum 3D7 strain. Here we present the detailed biochemical characterization of PfPSH2. PfPSH2 is DNA and RNA stimulated ATPase and is able to unwind partially duplex DNA and RNA substrates. It can translocate in both 3' to 5' and 5' to 3' directions. PfPSH2 is expressed in all the stages of intraerythrocytic development and it is

SUBMITTER: Chauhan M 

PROVIDER: S-EPMC6365506 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature