Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults.

ABSTRACT: Lifestyle contributes to inter-individual variability in brain aging, but previous studies focused on the effects of single lifestyle variables. Here, we studied the combined and individual contributions of four lifestyle variables - alcohol consumption, smoking, physical activity, and social integration - to brain structure and functional connectivity in a population-based cohort of 549 older adults. A combined lifestyle risk score was associated with decreased gyrification in left premotor and right prefrontal cortex, and higher functional connectivity to sensorimotor and prefrontal cortex. While structural differences were driven by alcohol consumption, physical activity, and social integration, higher functional connectivity was driven by smoking. Results suggest that combining differe

SUBMITTER: Bittner N 

PROVIDER: S-EPMC6365564 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature