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Differential expression of CXCR3 and CCR6 on CD4⁺ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome.

ABSTRACT: Immune reconstitution inflammatory syndrome (IRIS) occurs in up to 40% of individuals co-infected with pulmonary tuberculosis (PTB) and HIV, primarily upon antiretroviral therapy (ART) initiation. Phenotypic changes in T-cells during TB-IRIS and their relationship with systemic inflammation are not fully understood. In this prospective cohort study, we followed 48 HIV-positive patients with PTB from South India before and after ART initiation, examining T-lymphocyte subsets and inflammatory biomarkers in peripheral blood. Quantification of naïve (CD27⁺CD45RO^-) as well as effector memory CD4⁺ T cells (CD27^-CD45RO⁺) at weeks 2-6 after ART initiation could distinguish TB-IRIS from non-IRIS individuals. Additional analyses revealed that AR

SUBMITTER: Silveira-Mattos PS

PROVIDER: S-EPMC6365576 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Differential expression of CXCR3 and CCR6 on CD4⁺ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Differential expression of CXCR3 and CCR6 on CD4+ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Differential expression of CXCR3 and CCR6 on CD4⁺ T-lymphocytes with distinct memory phenotypes characterizes tuberculosis-associated immune reconstitution inflammatory syndrome.