Cerebral serotonin transporter measurements with [¹¹C]DASB: A review on acquisition and preprocessing across 21 PET centres.

ABSTRACT: Positron Emission Tomography (PET) imaging has become a prominent tool to capture the spatiotemporal distribution of neurotransmitters and receptors in the brain. The outcome of a PET study can, however, potentially be obscured by suboptimal and/or inconsistent choices made in complex processing pipelines required to reach a quantitative estimate of radioligand binding. Variations in subject selection, experimental design, data acquisition, preprocessing, and statistical analysis may lead to different outcomes and neurobiological interpretations. We here review the approaches used in 105 original research articles published by 21 different PET centres, using the tracer [¹¹C]DASB for quantification of cerebral serotonin transporter binding, as an exemplary case. We highlight and

SUBMITTER: Norgaard M 

PROVIDER: S-EPMC6365604 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature