Causes, patterns and severity of androgen excess in 487 consecutively recruited pre- and post-pubertal children.

ABSTRACT: Objective Androgen excess in childhood is a common presentation and may signify sinister underlying pathology. Data describing its patterns and severity are scarce, limiting the information available for clinical decision processes. Here, we examined the differential diagnostic value of serum DHEAS, androstenedione (A4) and testosterone in childhood androgen excess. Design Retrospective review of all children undergoing serum androgen measurement at a single center over 5 years. Methods Serum A4 and testosterone were measured by tandem mass spectrometry and DHEAS by immunoassay. Patients with at least one increased androgen underwent phenotyping by clinical notes review. Results In 487 children with simultaneous DHEAS, A4 and testosterone measurements, we identified 199 with androgen exces

SUBMITTER: Idkowiak J 

PROVIDER: S-EPMC6365673 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature