Molecular mechanism of triple-negative breast cancer-associated BRCA1 and the identification of signaling pathways.

ABSTRACT: BRAC1 has multiple important interactions with triple-negative breast cancer, the specific molecular characteristics of this interaction, however, have not yet been completely elucidated. By examining cell signaling pathways, important information for comprehending the potential mechanisms of this cancer may become known. The aim of the present study was to identify the effects of BRAC1 and to find the signaling pathway(s) involved in the pathogenic mechanism of triple-negative breast cancer. In this study, GSE27447 microarray data were obtained from the Gene Expression Omnibus (GEO) database of the National Center for Biotechnology Information, and differentially expressed genes (DEGs) from GSE27447 were distinguished by Significant Analysis of Microarray. Gene ontology (GO) analysis was

SUBMITTER: Qi F 

PROVIDER: S-EPMC6365902 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature