A lexical semantic hub for heteromodal naming in middle fusiform gyrus.

ABSTRACT: Semantic memory underpins our understanding of objects, people, places, and ideas. Anomia, a disruption of semantic memory access, is the most common residual language disturbance and is seen in dementia and following injury to temporal cortex. While such anomia has been well characterized by lesion symptom mapping studies, its pathophysiology is not well understood. We hypothesize that inputs to the semantic memory system engage a specific heteromodal network hub that integrates lexical retrieval with the appropriate semantic content. Such a network hub has been proposed by others, but has thus far eluded precise spatiotemporal delineation. This limitation in our understanding of semantic memory has impeded progress in the treatment of anomia. We evaluated the cortical structure and dynam

SUBMITTER: Forseth KJ 

PROVIDER: S-EPMC6365955 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature