Seventy Years of Chlamydia Vaccine Research - Limitations of the Past and Directions for the Future.

ABSTRACT: Chlamydia is a major bacterial pathogen that infects humans, as well as a wide range of animals, including marsupials, birds, cats, pigs, cattle, and sheep. Antibiotics are the only treatment currently available, however, with high rates of re-infection, there is mounting pressure to develop Chlamydia vaccines. In this review, we analyzed how Chlamydia vaccine trials have developed over the past 70 years and identified where future trials need to be focused. There has been a strong bias toward studies targeting C. muridarum and C. trachomatis within mice and a lack of studies matching chlamydial species to their end target host. Even though a large number of specific antigenic targets have been studied, the results from whole-cell vaccine targets show sli

SUBMITTER: Phillips S 

PROVIDER: S-EPMC6365973 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature