Are we there yet with patent foramen ovale closure for secondary prevention in cryptogenic stroke? A systematic review and meta-analysis of randomized trials.

ABSTRACT:

Background

We performed a meta-analysis to evaluate the benefit of patent foramen ovale closure in stroke prevention.

Methods

We searched Medline/PubMed, EMBASE, Web of Science and Cochrane central database for randomized control trials assessing the incidence of recurrent stroke after patent foramen ovale closure when compared to medical therapy. Pooled odds ratio and 95% confidence intervals were calculated using a random effects model. The heterogeneity among studies was tested using the χ² test and inconsistency was quantified using the I² statistic.

Results

Our search strategy yielded 71 articles. We included five studies with a total of 3440 patients. Median age in the device group was 45 (43, 5.5) years and in the medical group was 45 (44.

SUBMITTER: Agasthi P 

PROVIDER: S-EPMC6365999 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature