TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis.

ABSTRACT:

Background

In our previous study, we identified a candidate tumor suppressor gene, testin LIM domain protein (TES), in primary gastric cancer (GC). TES contains three LIM domains, which are specific interacting regions for the cell adhesion and cytoskeleton regulatory proteins. Mena is a known cytoskeleton regulator that regulates the assembly of actin filaments and modulates cell adhesion and motility by interacting with Lamellipodin (Lpd). Therefore, we hypothesized that TES plays a role as tumor suppressor in GC through interacting with Mena. This study aimed to investigate the tumor suppressive functions of TES in GC.

Methods

We explored the tumor suppressive effect of TES in GC by in vitro cell proliferation assay, colony formation assay, cell cycle analysis, Transwell

SUBMITTER: Wang DD 

PROVIDER: S-EPMC6366075 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature