Important advances in Alzheimer's disease from the use of induced pluripotent stem cells.

ABSTRACT: Among the various types of dementia, Alzheimer's disease (AD) is the most prevalent and is clinically defined as the appearance of progressive deficits in cognition and memory. Considering that AD is a central nervous system disease, getting tissue from the patient to study the disease before death is challenging. The discovery of the technique called induced pluripotent stem cells (iPSCs) allows to reprogram the patient's somatic cells to a pluripotent state by the forced expression of a defined set of transcription factors. Many studies have shown promising results and made important conclusions beyond AD using iPSCs approach. Due to the accumulating knowledge related to this topic and the important advances obtained until now, we review, using PubMed, and present an update of all public

SUBMITTER: Majolo F 

PROVIDER: S-EPMC6366077 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature