A new technique for predicting intrinsically disordered regions based on average distance map constructed with inter-residue average distance statistics.

ABSTRACT:

Background

It had long been thought that a protein exhibits its specific function through its own specific 3D-structure under physiological conditions. However, subsequent research has shown that there are many proteins without specific 3D-structures under physiological conditions, so-called intrinsically disordered proteins (IDPs). This study presents a new technique for predicting intrinsically disordered regions in a protein, based on our average distance map (ADM) technique. The ADM technique was developed to predict compact regions or structural domains in a protein. In a protein containing partially disordered regions, a domain region is likely to be ordered, thus it is unlikely that a disordered region would be part of any domain. Therefore, the ADM technique is expected to

SUBMITTER: Shimomura T 

PROVIDER: S-EPMC6366092 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature