Genetic segregation of airway disease traits despite redundancy of calcium-activated chloride channel family members.

ABSTRACT: Complex airway diseases such as asthma and chronic obstructive pulmonary disease exhibit stereotyped traits (especially airway hyperreactivity and mucous cell metaplasia) that are variably expressed in each patient. Here, we used a mouse model for virus-induced long-term expression of these traits to determine whether individual traits can be genetically segregated and thereby linked to separate determinants. We showed that an F2 intercross population derived from susceptible and nonsusceptible mouse strains can manifest individual phenotypic extremes that exhibit one or the other disease trait. Functional genomic analysis of these extremes further indicated that a member of the calcium-activated chloride channel (CLCA) gene family designated mClca3 was inducible with mucous cell metaplasi

SUBMITTER: Patel AC 

PROVIDER: S-EPMC6366330 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature