Adherence is the critical factor for achieving molecular responses in patients with chronic myeloid leukemia who achieve complete cytogenetic responses on imatinib.

ABSTRACT:

Purpose

There is a considerable variability in the level of molecular responses achieved with imatinib therapy in patients with chronic myeloid leukemia (CML). These differences could result from variable therapy adherence.

Methods

Eighty-seven patients with chronic-phase CML treated with imatinib 400 mg/d for a median of 59.7 months (range, 25 to 104 months) who had achieved complete cytogenetic response had adherence monitored during a 3-month period by using a microelectronic monitoring device. Adherence was correlated with levels of molecular response. Other factors that could influence outcome were also analyzed.

Results

Median adherence rate was 98% (range, 24% to 104%). Twenty-three patients (26.4%) had adherence

SUBMITTER: Marin D 

PROVIDER: S-EPMC6366340 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature