Longitudinal change of FEV₁ and inspiratory capacity: clinical implication and relevance to exacerbation risk in patients with COPD.

ABSTRACT:

Background and objective

FEV₁ is the gold standard for assessment of COPD. We compared efficacy of FEV₁, inspiratory capacity (IC), and IC to total lung capacity (TLC) ratio in the evaluation of COPD and their association with exacerbation.

Methods

We analyzed the association of dyspnea severity, quality of life status, and lung function with lung function measurements and exacerbation risk in 982 patients enrolled in the Korea COPD Subgroup Registry and Subtype Research study. Exacerbation and longitudinal lung function change were evaluated in 3 years' follow-up.

Results

The FEV₁, IC, and IC to TLC ratio showed comparable negative correlations with dyspnea severity and quality of life status, and positive correlation with exercise ca

SUBMITTER: Jo YS 

PROVIDER: S-EPMC6366360 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature